1. Research and development of stem cell drugs, tissue engineering scaffolds, tissue engineering cartilage, tissue engineered-meniscus, tissue engineered-ligaments and artificial ligaments, and tissue engineered-bone. Nanomaterials, functional small molecules, microenvironmental regulation, role of stem cells in tissue regeneration. Stem cells and regenerative medicine related molecular mechanisms, target molecules, bioinformatics analysis, multi-omics analysis, and single-cell sequencing research.

2. Research on molecular subtypes, susceptibility genes, molecular mechanisms and therapeutic target molecules, stem cell therapy and stem cell delivery system therapy of OA.

3. Studies on bionic anatomical reconstruction of anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL), allogeneic and xenogenic tissue transplantation reconstruction, brain regions activation related to cruciate ligament injury or/and reconstruction and return-to-sport after cruciate ligament injury or/and reconstruction, susceptibility genes and genetic diagnosis for cruciate ligament rupture.

4. Research on repair and reconstruction of knee meniscus injury or/and surgery, total or partial meniscus transplantation of allogeneic and xenogeneic meniscus grafts, meniscus regeneration related to meniscus injury, and knee joint degeneration related to meniscus injury.

5. Research on allogeneic and xenogeneic osteochondral transplantation reconstruction for knee osteochondral defects, intraoperative real-time patient-to-patient osteochondral transplantation reconstruction, autologous stem cell transplantation for articular cartilage repair, and intraoperative in situ 3D bioprinting for repair and reconstruction of cartilage injury.

6. Clinical threshold studies for surgical indications of patellofemoral joint disorders, innovative surgical procedures researches, research on pedigree with patellar femoral disorder, study on susceptibility genes and its genetic diagnosis.

7. Artificial intelligence-assisted diagnosis and treatment for bone and joint injuries, preoperative planning, surgical navigation, surgical robots, intraoperative and postoperative intelligent evaluation, and remote intelligent rehabilitation research.

8. Research and clinical application of personalized diagnosis and treatment technology, personalized surgical technology, intraoperative personalized medical devices and related medical equipment for bone and joint injuries.

1. Zhang ZZ#, Jiang D#, Wang SJ, Qi YS, Zhang JY, Yu JK *(通信作者). The potential of centrifugal seeding method in improving cells distribution and proliferation on the demineralized cancellous bone scaffolds for tissue engineered meniscus. ACS Appl Mater Interfaces. 2015, 7(28): 15294-302 PMID: 26102091. Doi: 10.1021/acsami.5b03129.

2. Zhang ZZ#, Jiang D#, Ding JX,* Wang SJ, Zhang L, Zhang JY, Qi YS, Chen XS, Yu JK*. Role of scaffold mean pore size in meniscus regeneration. Acta Biomater. 2016, 43: 314-326. Doi: 10.1016/j.actbio.2016.07.050. PubMed PMID: 27481291.

3. Zheng-Zheng Zhang#, You-Rong Chen#, Shao-Jie Wang#, Feng Zhao#, Xiao-Gang Wang, Fei Yang, Jin-Jun Shi, Zi-Gang Ge, Wen-Yu Ding, Yu-Chen Yang, Tong-Qiang Zou, Ji-Ying Zhang, Jia-Kuo Yu,* and Dong Jiang*. Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus. Sci Transl Med. 2019，11（487）: eaao0750. DOI: 10.1126/scitranslmed.aao0750.

4. Wang SJ#, Jiang D# , Zhang ZZ#, Chen YR, Yang ZD, Zhang JY, Shi J*(共同通讯作者), Wang X*, Yu JK*. Biomimetic Nanosilica-Collagen Scaffolds for In Situ Bone Regeneration: Toward a Cell-Free, One-Step Surgery. Adv Mater. 2019, 31(49): e1904341. Doi: 10.1002/adma.201904341. Epub 2019 Oct 17. PMID: 31621958.

5. Feifei Sun#, Yazhong Bu#, Yourong Chen, Fei Yang, Jiakuo Yu*, and Decheng Wu*. An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing. ACS APPLIED MATERIALS & INTERFACES 2020, 12(8):9132-9140. 20221129. Doi: 10.1021/acsami.0c01022.

6. Yanyu Yang#, Yatian Yang#, Yanxia Cao, Xing Wang⁎, Yourong Chen, Hongyan Liu, Yafei Gao, Jianfeng Wang, Chao Liu, Wanjie Wang⁎, Jia-Kuo Yu⁎, Decheng Wu⁎ . Anti-freezing, resilient and tough hydrogels for sensitive and large-range strain and pressure sensors. Chemical Engineering Journal 2021，403:126431. Received 20 May 2020; Received in revised form 10 July 2020; Accepted 23 July 2020; Available online 27 July 2020. Doi: 10.1016/j.cej.2020.126431（ESI highly cited）.

7. Yan X#, Yang B#, Chen YR#, Song YF, Ye J, Pan YF, Zhou BN, Wang YQ, Mao FB, Dong YC, Liu DS*, Yu JK*. Anti-Friction MSCs Delivery system improves the therapy for severe osteoarthritis. Advanced materials. 2021 Oct 17; e2104758. Doi: 10.1002/adma.202104758.

8. Fan BS#, Ye J#, Xu BB#, Sun ZW, Zhang JY, Song ST, Wang XJ, Song YF, Zhang ZZ*, Jiang D*, Yu JK*. Study on feasibility of the partial meniscal allograft transplantation. Clin Transl Med. 2022, 12(1): e701. Doi: 10.1002/ctm2.701. PMID: 35088938.

9. Meng Yang#, Zheng-Chu Zhang#, Fu-ZhenYuan#, Rong-Hui Deng, XinYan, Feng-Biao Mao, You-Rong Chen*, Hua Lu*, Jia-KuoYu*. An immunomodulatory polypeptide hydrogel for osteochondral defect repair. Bioact Mater. 2022, 19: 678-689. (IF=18.9, Q1). (January 2021) . Doi: 10.1016/j.bioactmat.2022.05.008（ESI highly cited）.

10. Bingbing Xu#, Jing Ye#, Bao-Shi Fan, Xinjie Wang, Ji-Ying Zhang, Shitang Song, Yifan Song, Wen-Bo Jian*, Xing Wang*, Jia-Kuo Yu*. Protein-spatiotemporal partition releasing gradient porous scaffolds and anti-inflammatory and antioxidant regulation remodel tissue engineered anisotropic meniscus. Bioact Mater. 2022, 20: 194-207. (January 2021) . doi: 10.1016/j.bioactmat.2022.05.019（ESI highly cited）.

11. Chen YR#, Yan X#, Yuan FZ#, Lin L, Wang SJ, Ye J, Zhang JY, Yang M, Wu DC*, Wang X*, Yu JK*. Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair. Adv Sci (Weinh). 2022 Oct17:e2105571. Doi: 10.1002/advs.202105571. Online ahead of print.PMID: 36253092.

12. Lei Liu#, Yiwen Xian#, Wantao Wang , Lin Huang, Jinghao Fan, Wenzheng Ma, Yixi Li, Hongmei Liu*, Jia-Kuo Yu*, Decheng Wu*. Meniscus-Inspired Self-Lubricating and Friction-Responsive Hydrogels for Protecting Articular Cartilage and Improving Exercise. ACS Nano 2023 Dec 12;17(23): 24308-24319. doi: 10.1021/acsnano.3c10139. Epub 2023 Nov 17. （JCR，Q1，IF 17.1）.

13. Chao Li#, Ronghui Deng#, Meng Yang, Fuzhen Yuan, Chong Zhang, and Jiakuo Yu*. Advanced Hydrogel Material for Meniscus Repair. Adv. Funct. Mater. 2024, 2312276. DOI: 10.1002/adfm.202312276.

14. Jing Ye#, Ronghui Deng#, Xinjie Wang#, Shitang Song, Xiong Xu, Ji-Ying Zhang, Bing-Bing Xu*, Xing Wang*, Jia-Kuo Yu*. Intra-articular Histone Deacetylase Inhibitor Microcarrier Delivery to Reduce Osteoarthritis. Nano Lett. 2023 Dec 13;23(23):10832-10840. Epub 2023 Nov 27. PMID: 38009465. PMCID: PMC10722529. DOI: 10.1021/acs.nanolett.3c03037.

15. RONGHUI DENG#, RUIFANG ZHAO#, ZINING ZHANG, YANG CHEN, MENG YANG, YIXUAN LIN, JING YE, NAN LI, HAO QIN, XIN YAN, JIAN SHI, FUZHEN YUAN, SHITANG SONG, ZIJIE XU, YIFAN SONG, JIANGNAN FU, BINGBING XU, GUANGJUN NIE* , AND JIA-KUO YU*. Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. SCIENCE TRANSLATIONAL MEDICINE, 21 Feb 2024, Vol 16, Issue 735, DOI: 10.1126/scitranslmed.adh9751.

Founding Chairman of the Geriatric Sports Medicine Branch of the Chinese Society of Gerology and Geriatrics.

Enjoys the Special Government Allowance of The State Council of the People’s Republic of China.

Health Consultation Expert of CPC Central Committee

Medical Expert of the National Team for Summer and Winter Olympic Games.

Chief editor of Arthroscopy and Sports Medicine of the Fifth Editorial Board of Orthopedic Journal of China

Associate Editor of Chinese Journal of Sports Medicine

Executive Editor of Chinese Journal of Bone and Joint Surgery

Editorial Board Members of several other Journals.

Vice Presidents and Vice Chairmans of 7 Societies.

Email: yujiakuo@tsinghua.edu.cn