乐竞在线官网-中国有限公司官网

刘清飞

刘清飞，副教授

E-mail: liuqf@tsinghua.edu.cn

Tel: +86-10-62797450

个人简历
荣誉和奖励
代表论著

清华大学药学院党委书记，药学实验教学中心（校级）主任，清华大学北京市中医药交叉研究所常务副所长。1993年毕业于陕西中乐竞在线官网药学系，获学士学位；2000年毕业于南京中医药大学中药学院，获硕士学位；2003年毕业于广州中医药大学中药学院，获博士学位；2003-2005年于清华大学化学系从事博士后研究工作；2005年于乐竞工作，其中2009年于比利时鲁汶大学生物系从事博士后研究工作，2011年11月比利时鲁汶大学乐竞在线官网访问学者；2015年12月起于清华大学药学院（原乐竞在线官网药学系）工作，其中2017年7月于英国牛津大学EMI项目研修。

承担欧盟Horizon2020、科技部国际合作重点项目、国家自然科学基金、科技部科技攻关、粤港澳科技合作、中国博士后科研课题（一等）、清华大学-鲁汶大学合作项目等科研项目。参与首个网络药理学国际标准的制订，出版合著专著4部，参与翻译著作1部，其中《中医药系统生物学》（中、英文版）为国内外第一部中医药系统生物学研究专著。

课程教学

（1）专业课程：《药剂学》（清华大学精品课、课程思政示范课），《药剂学实验》，《药学综合实验》，《药学社会实践》。

（2）清华大学通识课程：《传统与现代：中医药科学研究进展》。

（3）探究课：《实验室科研探究》第八十三单元。

研究方向

（1）专业课程：《药剂学》（清华大学精品课、课程思政示范课），《药剂学实验》，《药学综合实验》，《药学社会实践》。

（2）清华大学通识课程：《传统与现代：中医药科学研究进展》。

（3）探究课：《实验室科研探究》第八十三单元。

北京市普通高校本科毕业设计论文优秀指导教师（2022）；首都大学生社会实践先进工作者（2022）；清华大学先进工作者（2021）；清华大学课程思政示范教师（2023）；清华大学优秀教学奖（2022，2021，2019）；清华大学教学成果奖（2021，2016）；清华大学实验技术成果奖（2022，2016，2014）；清华大学刘冰奖（2019）；清华大学优秀党支部书记（2019）；清华大学学生社会实践优秀指导教师（2022，2018）；清华大学教师身份林枫辅导员奖（2017）；清华大学优秀党建与思想政治工作者（2017）；清华大学就业工作先进个人（2016）；清华大学“挑战杯”优秀指导教师（2016）；清华大学宣传工作先进个人（2014）。

专著

1. Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu. System biology for TCM, John Wiley Press, 2012；

2. 罗国安，王义明，梁琼麟， 刘清飞。中医药系统生物学。科学出版社，2011；

3. 药物新剂型。编委，化学工业出版社，2003。

论文

1. Jing Jiang, Fuguo Han, Kaixuan Cai, Qiushuo Shen, Cuiping Yang, Anli Gao, Juan Yu, Xuemei Fan, Yanli Hao, Zhao Wang, Weiping Liu*, Yun Shi*, Qingfei Liu*. Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer. Journal of Inorganic Biochemistry, 2023, 243, 112200.

2. Yifei Liu, Xuemei Fan, Huanhuan Pang, Saiya Liu, Bohong Wang, Chunmei Wang, Qingya Yan, Wenping Song, Zeping Hu*, Qingfei Liu*, Yun Shi*. Metabolomics reveals a panel of biomarkers for early human embryonic development arrest. Journal of Proteome Research, 2023, 22, 1280-1286.

3. Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu*, Yun Shi*. Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation. Bioscience Report, 2021, 41, BSR20203955.

4. Xianzhi Su, Xiaomei Wang, Yifei Liu, Wenjuan Kong, Fei Yan, Fuguo Han, Qingfei Liu*, Yun Shi*. Effect of Jiajian Guishen Formula on the senescence-associated heterochromatic foci in mouse ovaria after induction of premature ovarian aging by the endocrine-disrupting agent 4-vinylcyclohexene diepoxide. Journal of Ethnopharmacology, 2021, 269, 113720.

5 Yingxue Li, Fanzhuo Meng, Zhijian Chen, Fuguo Han, Donglin He, Anli Gao, Jing Jiang, Weiping Liu*, Qingfei Liu*. Pharmacokinetics and tissue distribution of a novel anticancer platinum compound LLC-1903 to rats. Xenobiotica, 2020, 50(8), 980-987.

6. Huang Qing; Li Liyuan; Chen Huiling; Liu Qingfei*; Wang Zhao*. GPP (composition of Ganoderma lucidum poly-saccharides and Polyporus umbellatus poly-saccharides) enhances innate immune function in Mice. Nutrients, 2019, 11, 1480.

7. Chen Huiling; Huang Qing; Zhang Shunjia; Hu Kaiqiang; Xiong Wenxiang; Xiao Lingyun; Cong Renhuai; Liu Qingfei*; Wang Zhao*. The Chinese herbal formula PAPZ ameliorates behavioral abnormalities in depressive mice. Nutrients, 2019, 11(4), 859.

8. Huan-Huan Qiao, Fang Wang, Rong-Gang Xu, Jin Sun, Ruibao Zhu, Decai Mao, Xingjie Ren, Xia Wang, Yu Jia, Ping Peng, Da Shen, Lu-Ping Liu, Zhijie Chang, Guirong Wang, Shao Li, Jun-Yuan Ji, Qingfei Liu, Jian-Quan Ni*. An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. Nature Communications, 2018, 9, 4160.

9. Yu Jia, Rong-Gang Xua, Xingjie Ren, Ben Ewen-Campenc, Rajendhran Rajakumar, Jonathan Zirin, Donghui Yang-Zhou, Ruibao Zhu, Fang Wang, Decai Mao, Ping Peng, Huan-Huan Qiao, Xia Wang, Lu-Ping Liu, Bowen Xu, Jun-Yuan Ji, Qingfei Liu, Jin Sun, Norbert Perrimon, and Jian-Quan Ni*. Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. PNAS, 2018, 115(18), 4719-4724.

10. Ren Xingjie; Holsteens Kristof; Li Haiyi; Sun Jin; Zhang Yifan; Liu Lu-Ping; Liu Qingfei*; Ni Jianquan*. Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system. Science China-life Sciences, 2017, 60(5), 476-489.

11. Donglin He, Shuhui Yin, Fuguo Han, Jingjie Zhu, Yun Shi, Zhiyuan Tong, Qingfei Liu*. Pharmacokinetics and tissue distribution of two novel isomerism anticancer platinum compounds. Drug Development and Industrial Pharmacy, 2016, 42(11), 1792-1799.

12. Zhengguang Li, Rui Zhang, Xiuping Wang, Xiaofei Hu, Yuguo Chen*, Qingfei Liu*. Simultaneous determination of seven ginsenosides in rat plasma by high performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection. Biomedical Chromatography, 2015, 29(2), 167-175.

13. Qingfei Liu, Yun Shi, Tuo Guo, Yong Wang, Wenjuan Cong, Jingjie Zhu. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography B, 2012, 907, 146-153.

14．Qingfei Liu, Walter Luyten, Klaartje Pellens, Yiming Wang, Wei Wang, Karin Thevissen, Qionglin Liang, Bruno P.A. Cammue, Liliane Schoofs, Guoan Luo. Screening for antifungal plants from Chinese traditional and folk medicines, Journal of Ethnopharmacology, 2012, 143(3), 772-778.

15．Jun Shi, Qingfei Liu*, Yiming Wang, Guoan Luo*. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. Pharmacology, Biochemistry and Behavior, 2010, 96, 449-453.

16. Wenjuan Cong, Qingfei Liu*, Xi Chen, Rong Gao, Juan Lu, Yiming Wang, Guoan Luo*. Characterization and pharmacokinetics of a novel pirarubicin liposome powder. Drug Development and Industrial Pharmacy, 2010, 143, 154-160.

17. Wenjuan Cong, Qingfei Liu*, Yiming Wang, Guoan Luo*. Investigation on the interactions between pirarubicin and phospholipids. Biophysical Chemistry, 2009, 143, 154-160.

18. Qingfei Liu, Yun Shi, Yong Wang, Juan Lu, Wenjuan Cong, Guoan Luo, Yiming Wang. Metabolism profile of scutellarin in rat urine following oral administration by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Talanta, 2009, 80, 84-91.

19．Qingfei Liu，Yun Shi, Yuzhen Zhang, Zhongmin Song, Qiang Su, Yu Zhang, Guoan Luo. A simple and rapid method for determination of pennogenin diglycoside in rat plasma by high performance liquid chromatography mass spectrometry: application to the pharmacokinetics of Gongxuening Capsules. Journal of Chromatographic Science, 2009, 47(8), 728-732.

20. Qingfei Liu, Xue Li, Qiang Su，Guoan Luo, Yiming Wang, Weiping Liu. Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats. Archives of Pharmacal Research, 2009, 32 (11), 1621-1628.

21. Su Qiang, Liu Qingfei*, Wang Yong, Bi Kaishun, Luo Guoan*. Rapid and sensitive assay on the main components in Shuang-Huang-Lian preparations by UPLC-TOF-MS. Chemical Research in Chinese Universities, 2009, 25(1), 122-124.

22. Qingfei Liu, Xiangdong Liu, Guoan Luo, Weiwei Tian, Yiming Wang. Determination of helicidum and its metabolites in dog plasma by LC/UV/MS/MS and its application to pharmacokinetic studies. Journal of Chromatography B, 2006, 832, 185-190.

刘清飞

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