3）研究领域：

细菌的群体行为及耐受性：自然状态的细菌常形成紧密聚集的群落，以生物被膜的形态存在。生物被膜广泛存在于我们生活中，并与人体健康息息相关。很多细菌感染都涉及到生物被膜。此外，生物被膜还常附着于医疗器械的表面，为公共健康带来极大的隐患。在群体状态下，细菌对药物及人体免疫系统有很强的耐受性。因此，生物被膜常导致持续性感染并难以根除。刘锦涛实验室运用多学科的理论和定量的研究方法，聚焦于对生物被膜的群体行为及其动态特性进行深入的研究，探索细菌群体中的新规律及其与人体健康的关系。

4）科学贡献：

首次发现了细菌间的相互合作与竞争导致生物被膜周期性减缓生长的新现象及其机制（Nature 2015, Science 2017）；开发了定量研究细菌群体的新方法（Small Science 2022, Nature Chemical Biology 2023）；揭示了细菌群体跨区域代谢交互的新模式（Nature Chemical Biology 2023）；发现了细菌对抗生素以及噬菌体耐受性的新机制（Nature Chemical Biology 2024, Nature Communications 2024, Science Advances 2024）。

5）荣誉奖励：

2018 国家高层次海外青年人才

2018 求是科技基金会杰出青年学者

6) 代表性论文：

1. Q. Hu, L. Huang, Y. Yang, Y. Xiang, J. Liu. Essential phage component induces resistance of bacterial community. Science Advances (2024). https://doi.org/10.1126/sciadv.adp5057

2. Y. Zhang, Y. Cai, X. Jin, Q. Wu, F. Bai, J. Liu. Persistent glucose consumption under antibiotic treatment protects bacterial community. Nature Chemical Biology (2024). https://doi.org/10.1038/s41589-024-01708-z

3. Y. Zheng, R. Chai, T. Wang, Z. Xu, Y. He, P. Shen, J. Liu. RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution. Nature Communications 15, 6579 (2024).

4. T. Wang, P. Shen, Y. He, Y. Zhang, J. Liu. Spatial transcriptome uncovers rich coordination of metabolism in E. coli K12 biofilm. Nature Chemical Biology 19, 940-950 (2023).

5. T. Wang, P. Shen, R. Chai, Y. He, J. Liu. Profiling of bacterial transcriptome from ultra-low input with MiniBac-seq. Environmental Microbiology 24, 5774–5787 (2022).

6. Y. Zhang, Y. Cai, L. Zeng, P. Liu, L. Z. Ma, J. Liu. A Microfluidic Approach for Quantitative Study of Spatial Heterogeneity in Bacterial Biofilms. Small Science 2, 2200047 (2022).

7. J. Liu, R. Martinez-Corral, A. Prindle, D.-Y. D. Lee, J. Larkin, M. Gabalda-Sagarra, J. Garcia-Ojalvo, G. M. Süel, Coupling between distant biofilms and emergence of nutrient time-sharing. Science 356, 638–642 (2017).

8. J. Liu, A. Prindle, J. Humphries, M. Gabalda-Sagarra, M. Asally, D. D. Lee, S. Ly, J. Garcia-Ojalvo, G. M. Süel, Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature 523, 550–554 (2015).

Complete list of publications: https://orcid.org/0000-0002-6710-2605